CICA: IBS, Crohn's Array and Celiac Disease Test
Genetic - $494
HLA Typing for Celiac Disease Test –HLA -DQ2.5 and HLA-DQ8
More than 95% of patients with celiac disease possess HLA-DQ2.5 and/or HLA-DQ8 genotype. More than 90% of those with celiac have the DQ2.5 genotype. Absent these markers, development of celiac is highly unlikely.
The predominant genetic markers are:
- NOD2/CARD15 are associated with the innate immune system and the activation of nuclear factor кB (NF-кB).
- T300A mutation in the ATG16L1 gene increases its susceptibility to degradation by Caspase 3 and thus is associated with autophagy.
Antibody / Serology - $225
Total Serum IgA
It is not uncommon for CD patients to be IgA deficient. It is not only the most common immunologic deficiency ( 1:400-1:700 in the general population and 1:50 in CD patients) but may be the single largest contributor to false negative results in biopsy confirmed CD patients. It is used as a metric to qualify IgA testing for tTG and DGP antibody levels and when shown to be low or deficient why it is important to check IgG levels for both tTG and DGP.
Tissue Transglutaminase Antibody (tTG) - IgA & IgG
Measuring tissue transglutaminase antibody (tTg) is extremely useful as it is produced in the small intestine where gluten causes initial inflammation in sensitive people. It is often recommended as the initial Celiac Disease Test (CD) because of its high sensitivity (measuring the proportion of actual positives which are currently identified as such) and high specificity (measuring the proportion of actual negatives which are correctly identified as such) for CD.
Deamidated Gliadin Peptide (DGP) Antibody - IgA & IgG
This test detects antibodies binding synthetic deamidated gliadin-related peptides (DGP). Selective deamidation specifically increases the circulating antibody recognition of gliadin related peptides in CD patients. It is both highly sensitive and highly specific for active CD. Its high specificity is similar to that shown for tTG and even greater than that shown for previously tested antigliadin antibody (AGA).
Anti-Saccharomyces Cerevisiae Antibody (ASCA)
Because of an overlap with inflammatory bowel disease (IBD), specifically Crohn's Disease, (with patients showing gastrointestinal symptoms) the GHP includes ASCA. A positive ASCA test is associated with Crohn's Disease (59%-63%).
Take the CICA for IBS, Crohn's Array and Celiac Disease Test at home.